Action to control cardiovascular risk in diabetes eye study research group. Subjects and methods a total of 2,838 patients, who were aged 40 to 75 years and had type 2 diabetes without a documented history of cardiovascular disease and without elevated ldlcholesterol, were recruited from 32 centres in the uk and ireland and randomly allocated to atorvastatin. We estimated the costeffectiveness of atorvastatin in the primary prevention of cardiovascular events in patients with type 2 diabetes using data from the collaborative atorvastatin diabetes study cards. Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the collaborative atorvastatin diabetes study. An analysis from the collaborative atorvastatin diabetes study cards author links open overlay panel helen m. A post hoc analysis of data from the collaborative atorvastatin diabetes study cards, a randomised, placebocontrolled trial of 2,838.
The statin and diabetes link was investigated in the justification for the use of statins in prevention. Pdf design of the collaborative atorvastatin diabetes study. The collaborative atorvastatin diabetes study cards is the first large primary prevention study to focus specifically on the role of a statin in patients aged 4075 years with type 2 diabetes, but no signs or symptoms of preexisting vascular disease and who had only average or below average cholesterol levels. Intervention and event lowering in diabetes, cards collaborative atorvastatin diabetes study, aspen atorvastatin as prevention of coronary heart disease endpoints in patients with noninsulindependent diabetes mellitus, sparcl stroke prevention by aggressive reduction in cholesterol levels, and accord action to control. Design of the collaborative atorvastatin diabetes study. Costeffectiveness of atorvastatin in the prevention of. An overview of cards collaborative atorvastatin diabetes study primary prevention of cardiovascular disease with atorvastatin in type 2. Atorvastatin reduced cv events even in low ldl dm patients. Pdf effects of atorvastatin on kidney outcomes and. Pdf primary prevention of cardiovascular disease with. The collaborative atorvastatin diabetes study cards is the first randomized controlled trial that assessed the effectiveness and safety of using atorvastatin in patients with type 2 diabetes. Methods the collaborative atorvastatin diabetes study cards is a multicentre, randomized, placebocontrolled, doubleblind clinical trial of primary prevention of cardiovascular disease in patients with type 2 diabetes. Colhoun hm, betteridge dj, durrington pn, hitman ga, neil ha, livingstone sj, thomason mj, mackness mi, charltonmenys v, fuller jh. The collaborative atorvastatin diabetes study cards was a doubleblind, randomized, placebocontrolled, multicenter trial of atorvastatin 10 mgday for the primary prevention of cvd in type 2 diabetes.
Safety of atorvastatin in the collaborative atorvastatin diabetes study cards the safety and efficacy of sta the safety and efficacy of statins for cvd prevention is well established, yet some physicians have concerns about the longterm safety of this class. Cards abbreviation stands for collaborative atorvastatin diabetes study. To describe baseline characteristics of patients in the collaborative atorvastatin diabetes study cards, a randomized. Are statin trials in diabetes representative of realworld. The objective of this study was to evaluate the safety and tolerability of atorvastatin 10 mg compared with placebo in 2,838 patients with type 2 diabetes and no history of coronary heart disease who were enrolled in the collaborative atorvastatin diabetes study cards. An analysis from the collaborative atorvastatin diabetes study cards previous article solutesolver. The collaborative atorvastatin diabetes study cards 1 was a stunningly positive demonstration of the clinical benefit of statin therapy in patients with type 2 diabetes. The study received ethical approval both centrally and at each participating institution, and each patient gave written. Collaborative atorvastatin diabetes study cards and fol lowed for 3. For the prevention of cardiovascular disease, statins are a firstline treatment. The aim of the collaborative atorvastatin diabetes study cards was to assess the effectiveness of 10 mg of atorvastatin daily versus placebo in the primary prevention of cardiovascular disease in patients with type 2 diabetes. The collaborative atorvastatin diabetes study cards is the first large primary prevention study to focus specifically on the role of a statin in patients aged 4075 years with type 2 diabetes, but no signs or symptoms of pre. An overview of cards collaborative atorvastatin diabetes. A webbased tool for modeling urea kinetics for a broad range of hemodialysis schedules in multiple patients.
Ezetimibe added to statin therapy after acute coronary. A landmark lipitor study of patients with type 2 diabetes. Rapid emergence of effect of atorvastatin on cardiovascular outcomes in the collaborative atorvastatin diabetes study cards diabetologia, dec 2005 h. The safety and tolerability of atorvastatin 10 mg in the collaborative. The safety and tolerability of atorvastatin 10 mg in the. Baseline characteristics in the collaborative atorvastatin diabetes study cards in patients with type 2 diabetes. Abstract background there are few data on the role of lipid lowering in the primary prevention of coronary heart disease chd in diabetic. Primary prevention of cardiovascular disease with atorvastatin in. We conducted a post hoc analysis to compare the efficacy and safety of atorvastatin among 1,129 patients aged 6575 years at randomization with 1,709 younger patients in the collaborative atorvastatin diabetes study cards. Collaborative atorvastatin diabetes study cards 2838 primary prevention patients no ascvd with type 2 diabetes at least 1 other cv risk factor such as smoking, hypertension, retinopathy, or microalbuminuria ldlc levels. The role of statins in diabetes treatment diabetes spectrum. Design of the collaborative atorvastatin diabetes study cards. Evidence for the use of statins in patients with diabetes primary prevention trials in diabetes current clinical practice is based on relatively few randomized, control tri als.
What is the abbreviation for collaborative atorvastatin diabetes study. Population 56 963 patients with diabetes initiating statin use from 2005 to 2008. The collaborative atorvastatin diabetes study cards is a multicentre, randomized, placebocontrolled, doubleblind clinical trial of primary prevention of cardiovascular disease in patients with. Ironically, there is a very compelling clinical trial showing the value of one statin, lipitor atorvastatin, in type 2 diabetes the collaborative atorvastatin diabetes study known as cards.
In their analysis of the outcomes from cards, based on linear analysis, they determine the value of apolipoprotein b apob that corresponds to target values of ldl. An analysis from the collaborative atorvastatin diabetes study cards. The collaborative atorvastatin diabetes study cards. Trials like the collaborative atorvastatin diabetes study cards, proved beyond doubt that patients with type 2 diabetes and other risk factors for cvd should be treated with a statin, apparently disregarding their. Costeffectiveness of primary prevention of cardiovascular. Objective to assess the representativeness of the heart protection study hps and the collaborative atorvastatin diabetes study cards for incident statin users. The collaborative atorvastatin diabetes study cards is a multicentre, randomized, placebocontrolled, doubleblind clinical trial of primary. Lipid management in type 2 diabetes clinical diabetes.
Patients with type 2 diabetes and no prior cvd n 2,838. The collaborative atorvastatin diabetes study cards randomized placebocontrolled trial. Design a populationbased analysis with linked register data. Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the collaborative atorvastatin diabetes study cards. Renal effects of atorvastatin and rosuvastatin in patients. Atorvastatin, sold under the brand name lipitor among others, is a statin medication used to prevent cardiovascular disease in those at high risk and treat abnormal lipid levels. Kdigo clinical practice guideline for lipid management in. In the collaborative atorvastatin diabetes study cards, the effect of lipitor atorvastatin calcium on cardiovascular disease cvd endpoints was assessed in 2838. Common side effects include joint pain, diarrhea, heartburn, nausea, and muscle pains. Effects of atorvastatin on kidney outcomes and cardiovascular disease in patients with diabetes.
Main outcome measures we determined the proportions of realworld. Atorvastatin reduced major cardiovascular disease events. Collaborative atorvastatin diabetes study american. Rapid emergence of effect of atorvastatin on cardiovascular. American diabetes association indications for statins in. These guidelines are based on numerous trials showing a benefit for statin therapy both as primary and secondary prevention of cardiovascular disease and mortality 27. The trial was stopped 2 years earlier than planned because of significant benefit at the second interim analysis. The primary objective is to investigate whether treatment with the hydroxymethylglutaryl coenzyme a reductase inhibitor. The american diabetes association has recommended using statins a class of drug used to lower cholesterol levels for patients with type 2 diabetes. Among these studies1422 are the heart protection study hps,14 the collaborative atorvastatin diabetes study cards,15 the angloscandinavian cardiac outcomes. The collaborative atorvastatin diabetes study cards is the first large primary prevention study to focus specifically on the role of a statin in patients aged 4075 years with type 2 diabetes, but no signs or symptoms of preexisting vascular disease and who had only. In the collaborative atorvastatin diabetes study cards, the effect of lipitor on cardiovascular disease cvd endpoints was assessed in 2838 subjects 94% white, 68% male, ages 4075 with type 2 diabetes based on who criteria, without prior history of cardiovascular disease and with ldl. This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes cards overview 1 a multicenter randomized placebo controlled trial to determine hard outcomes of atorvastatin 10mg vs. Atorvastatin in patients with type 2 diabetes mellitus. An overview of cards collaborative atorvastatin diabetes study. The percentages of patients experiencing treatment associated adverse events. Analysis of efficacy and safety in patients aged 65. Safety of atorvastatin in the collaborative atorvastatin. Pdf baseline characteristics in the collaborative atorvastatin.
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